• An orbiting fly which deals 2 contact damage per tick to enemies.• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.• Of the two heart containers given from this item, only 1/2 a red heart of them is filled.• Has a chance to drop from the Super Gluttony miniboss fight.
- Spawns one blue attack spider for every enemy in the room. with enemies and the beams deal damage equal to your tear damage + 20.• Tears are now white, do a lot more damage and move slower across the screen with a homing effect. * item room, treasure room, item room pool, the lost item pool, starting, grey, gray• Tears are replaced with the ability to charge and fire a and many others.• An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool)* devil pool, devil room pool, devil deal, infinity, red, black• Has a chance to drop while playing any Blood Donation machine.UNLOCK: Unlock this item by playing the Blood Donation machine 30 times.• Gives you a high rate of fire in exchange for a damage down.Item Pool: Item Room, Secret Room, brown, purple, grey, gray* secret room pool, item room, treasure room, item room pool• +1 Health Up (The given heart container is empty)* secret room pool, item room, treasure room, item room pool, purple, pink• When you only have half a heart remaining or less, you enter a curse state which adds +1.5 damage and +0.3 speed.• When playing as Eve, this item activates with one FULL heart The effect triggers again 30 seconds after use and 60 seconds after use.Upon use, any trinkets that the player is holding are destroyed, and their effects are permanently applied to the player.Throws up the last pill you used. * astrology, astronomy, item room, treasure room, item room pool, ohm, blue, glow• Isaac's tears turn bright green and always apply a poison effect to enemies which deals 4 or 6 damage per tick.• This is essentially a superior version of The Common Cold item.• One of the twelve zodiac items available in the game. Flies spawned from a Mulligan dying.• When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies in close proximity and send a wave of spikes across the room in the direction you are facing.• The enemies in close range will take 5 damage then have a poison over time effect which deals your tear damage 4 or 6 times.• The spike wave will deal 10 damage to any enemies in contact with it.• When used, reduces your health to half a heart and fires one large piercing spectral tear that does a lot of damage.• This will affect all hearts including red, soul and black, reducing all of them down to half of one heart.• The damage done by Glass Cannon is calculated as follows: dmg = (dmg + 1) * 10 (i.e.
* angel room pool, god room pool, angel room item, item room, treasure room, item room pool, * item room, treasure room, item room pool, brown, orange, headless• When getting hit, this item has a chance to drop a soul heart or black heart.• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.• The chance to spawn a heart is affected by your luck stat and at +22 Luck it will activate 50% of the time.• Due to a bug, if you have more than 22 luck, Gimpy won't drop overall.• All 6 stats are affected by this item, including shot speed and luck.• At least one stat is reduced but no more than 3 stats are reduced.• Can kill Blue Baby if it removes health, but not other characters (This exception has been fixed for Afterbirth+).UNLOCK: Unlock this item by beating Mom's Heart 7 times. take damage.• Sharp Plug becomes useless with this item, due to how damage is prevented on Isaac's body.UNLOCK: Unlock this item by beating the Isaac boss with The Lost.• A familiar ghost that follows Isaac around and chases enemies * shop room pool, shop item pool, packet, deck, brown, orange• Allows for 2 pills to be held.
- Speeds up all enemies for the rest of the room. * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, beggar pool, normal judgement pool, coin beggar pool, coin judgement anything nearby.• The damage dealt from this item scales with your damage stat.• Essentially a one-time more powerful use of the Epic Fetus item. bean * item room, treasure room, item room pool, dollar, red, grey, gray, • Tears now have a random chance to freeze enemies in place.• The chance to freeze enemies is affected by your luck stat.• +0.25 Range Up.