Dr. Dan Regan Dr. Regan received his DVM degree from the University of Georgia in 2011, and subsequently completed his residency training in veterinary anatomic pathology (2014) and PhD (Comparative Pathology; 2017) in the Department of Microbiology, Immunology, and Pathology (DMIP) at Colorado State University. There was decreased retropulsion of the right eye.
Materials and methods: Male C57BL/6 mice were fed standa...PD-L1 is an immune checkpoint protein that has emerged as a major signaling molecule involved with tumor escape from T cell immune responses. Daniel Regan is a London based photographic artist and Artistic Director specialising in health and wellbeing. Pharmacologic and genetic autopha...Expression of programmed cell death receptor ligand 1 (PD-L1) on tumor cells has been associated with immune escape in human and murine cancers, but little is known regarding the immune regulation of PD-L1 expression by tumor cells and tumor-infiltrating macrophages in dogs.
Accumulation of visceral, but not subcutaneous, adipose tissue is highly associated with metabolic disease. MSC can suppress ongoing inflammatory responses by suppressing T cell function, while fewer studies have examined the impact of MSC on dendritic cell function. Therefore, 14 canine tumor cell lines, as well as primary cultures of cani...Background and Significance: PD-L1 is an immune checkpoint protein that has emerged as a major signaling molecule involved with tumor escape from T cell immune responses. The SIX1/EYA transcriptional complex plays a critical role in the development of multiple organs and is typically downregulated after development is complete. Obesity, predominately visceral adiposity, links to numerous diseases; hence, we postulate that secondary lymphatics within this region contributes to disease risk.
Four of eight tumors exhibited histological features similar to human retinoblastomas characterized by Flexner-Wintersteiner rosettes, and fleurettes, and demonstrated variable immunoreactivity for retinal...Equine recurrent uveitis (ERU) is a spontaneous disease that is the most common cause of blindness in horses, affecting up to 15% of the horse population.
flint animal cancer center newsletter The purpose of this study is to inve...An 11-year-old Fox Terrier dog was evaluated for a 10-month history of progressive exophthalmia and visual deficits in the right eye.
Th17 cells are a major cell population driving the pathogenesis in several mouse models of autoimmune inflammation, including experimental autoimmune uveitis. Until now, there have been no reported inhibitors of CHD1L, also limitin...Metastasis is the major cause of mortality for cancer patients, and dysregulation of developmental signaling pathways can significantly contribute to the metastatic process. The Pathology/Immuno-Pathology Laboratory is dedicated to the development and use of biomarker assays in cancer of companion and laboratory animals. The focus of Dr. Regan’s Investigational Pathology laboratory is to increase our understanding of the interplay between the immune system and (non-immune) tumor stroma, and how these compartments of the tumor microenvironment promote metastasis as well as respond to and mediate extrinsic mechanisms of resistance to anti-cancer therapy. Regan received his DVM degree from the University of Georgia in 2011. It is theorized that 3-D printed interbody cages utilizing porous titanium material can provide more consistent bone ingrowth and biological fixation. In theory, this would limit their use in a clinical setting after limb salvage treatment for osteosarcoma. To investigate this area of cancer biology, his laboratory utilizes a combination of in vitro 3-dimensional tumor co-culture models and animal models, focusing on breast and bone cancer (osteosarcoma).
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Daniel REGAN of Colorado State University, CO (CSU) | Read 44 publications | Contact Daniel REGAN However, MSC therapy ideally requires a convenient and relatively homogenous cell source (typically bone marrow or adipose tissues) and the ability to generate cells with stab...Obesity-related adverse health consequences occur predominately in individuals with upper body fat distribution commonly associated with increased central adiposity. This review will cover recent advances in cancer immunotherapy, including the use of T cell checkpoint inhibitors, engineered T cells, cancer vaccines, and anti-B cell and T cell antibodies. However, it has recently been shown that expression of PD-L1 on myeloid cells from the tumor is a stronger ind...Mesenchymal stem cells (MSC) from rodents and humans have been shown to suppress T cells by distinct primary pathways, with NO-dependent pathways dominating in rodents and IDO-dependent pathways dominating in humans. We studied the role of MSC in immune activation and subsequent recruitment of monocytes in suppres...Chronic bacterial infections associated with biofilm formation are often difficult to resolve without extended courses of antibiotic therapy. Since transmission of Leishmania is achieved exclusively by sand fly vectors via immune-modulati...Objectives: Studies have shown that intra-tumoral expression of PD-L1 can inhibit antitumor immune responses. Inflammation inciting from adipose tissue is commonly associated with metabolic disease risk and comorbidities.